For example; if someone you love dies, gets hurt, or becomes very sick, you're going to be sad about it. Your not going to say "sorry you died grandma, I can't grieve for you or be sad right now, because I'm trying to do some manifesting work and mama needs a brand new car!" Sounds silly, right? But you get my point. The same holds true for depression. Let's say that you just experienced a huge, life-changing, knockout. Are you going to smile and laugh and say "It's no big deal, I have plenty more dreams that can be shattered?" I sincerely doubt that would be your answer. You would be experiencing depression, and there's nothing wrong with that. Will it interfere with your manifesting rituals? Yes, it absolutely will, but eventually, you will be able to "LET GO," and begin again right where you left off.
The best advice I can give you is to accept and acknowledge your sadness and depression. The next thing you should do is "ALLOW" yourself the opportunity to heal, just as you "ALLOW" the universe to lead you to your desires. It's not a race, there's no one yelling "I win, I beat you getting out of my depression." The process is different for all of us beautiful souls, but if you at least try to be grateful and thankful, each day for one thing, no matter how small it is, then you will be on your way to healing. If, however, and I cannot stress this enough, your sadness or depression doesn't ease up or seem to be getting better at all, and it's been a long time, please, please, seek professional advice from your doctor or a licensed therapist. Sometimes we all need a little extra help and understanding, and there's nothing to be ashamed of.
LOVE TO ALL